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KMID : 1134820060350091178
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Journal of the Korean Society of Food Science and Nutrition
2006 Volume.35 No. 9 p.1178 ~ p.1184
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Effect of Antler Velvet Ethanol Extract on Common Serum Chemistry Panels and Histopathological Change in Rats Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
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Choi Kyung-Yun
Hwang Seock-Yeon
Lee Su-Chan
Kim Si-Kwan
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Abstract
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This study was carried out to investigate the effect of ethanol extract of antler velvet (EAV) on common serum chemistry panels and histopathological change in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Administration of TCDD (50 ㎍/㎏ body weight) induced significant decrease in platelet count (p＜0.01), creatine phosphokinase (CPK, p＜0.01), lactatate dehydrogenase (LDH, p＜0.05) and glucose (p＜0.05) levels and increase in hemoglobin (p＜0.05), aspartate aminotransferase (AST, p＜0.01), alanine amino-transferase (ALT, p＜0.05) and lipase activities (p＜0.05), and blood urea nitrogen (BUN, p＜0.05), triglyceride (p＜0.01) and low density lipoptotein cholesterol (LDL-C, p＜0.05) levels. However, pretreatment of EAV at daily dose of 20 ㎎/㎏ b.w. from 1 wk before TCDD exposure for 5 wks attenuated the abnormality of the overall serum chemistry panels but statistical difference between TE and TA groups was observed only in testicular weight (p＜0.01), LDH activity (p＜0.05), glucose (p＜0.05) and lipase activity (p＜0.01). In addition, TCDD induced significant histopathological changes including swelling, fatty metamorphosis, and vacuolar degeneration in liver; edema in proximal and distal convoluted tubules, and glomerulus in kidney; severe atrophy of red purple and appearance of significant number of macrophage in spleen; prominent atrophy and decrease in immune cells in thymus. On the other hand, administration of EAV attenuated histopathological damage induced by TCDD. These results further suggest that administration of EAV attenuates TCDD-induced testicular, liver, pancreatic, hematopoietic and nephrotic toxicities in rats.
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KEYWORD
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2,3,7,8-tetrachlodibenzo-p-dioxin(TCDD), ethanol extract of antler velvet(EAV), protective effect
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